little rest in between is the way to go to lose weight, it turns your anaerobic weightlifting workout into an aerobic workout.
Also unless you are doing steroids you shouldn't lift weights more than 4 days a week, your body just cannot recuperate fast enough without chemical enhancement to keep up with that type of stimulus.
I would assume that if he's 250 now he needs to lose weight not only to look better but for health reasons. 250 is a lot of weight to carry around all day.
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